DNA Computing Boosted by a Cationic Copolymer
نویسندگان
چکیده
منابع مشابه
Encapsulation of DNA by cationic diblock copolymer vesicles.
Encapsulation of dsDNA fragments (contour length 54 nm) by the cationic diblock copolymer poly(butadiene-b-N-methyl-4-vinyl pyridinium) [PBd-b-P4VPQ] has been studied with phase contrast, polarized light, and fluorescence microscopies, as well as scanning electron microscopy. Encapsulation was achieved with a single emulsion technique. For this purpose, an aqueous DNA solution is emulsified in ...
متن کاملMNAzyme-catalyzed nucleic acid detection enhanced by a cationic copolymer.
Multi-component nucleotide acid enzymes (MNAzymes) derived from RNase-mimic DNAzymes have potential as simple and accurate DNA detectors. To enhance the MNAzyme activity under multiple-turnover conditions, a cationic comb-type copolymer, PLL-g-Dex, that facilitates hybridization and strand exchange reactions of DNA was utilized. The copolymer increased the MNAzyme reaction rate by 200 times, al...
متن کاملDNA assembly and re-assembly activated by cationic comb-type copolymer.
Guanine-rich oligonucleotides, such as TG(4)T and TG(5)T, assemble into a tetramolecular quadruplexes with layers of G-quartets stabilized by coordination to monovalent cations. Association rates of the quadruplexes are extremely slow, likely owing to electrostatic repulsion among the four strands. We have shown that comb-type copolymers with a polycation backbone and abundant hydrophilic graft...
متن کاملNew computing paradigms suggested by DNA computing: computing by carving.
Inspired by the experiments in the emerging area of DNA computing, a somewhat unusual type of computation strategy was recently proposed by one of us: to generate a (large) set of candidate solutions of a problem, then remove the non-solutions such that what remains is the set of solutions. This has been called a computation by carving. This idea leads both to a speculation with possible import...
متن کاملImproved performance of a DNA nanomachine by cationic copolymers.
We have reported previously that the cationic comb-type copolymer, PLL-g-Dex, accelerated DNA strand exchange reaction while stabilizing DNA duplexes. In this research, we studied the effects of PLL-g-Dex on a DNA-fueled nanomachine. The copolymer enabled rapid and secure operations of the DNA nanomachine which utilized the structural transition between intramolecular G-quadruplex and intermole...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Functional Materials
سال: 2018
ISSN: 1616-301X,1616-3028
DOI: 10.1002/adfm.201707406